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Why does cyproheptadine cause weight gain? It has long been known that the administration of antihistamines can cause weight gain. In fact, one antihistamine, cyproheptadine, has been used for this purpose. One reason, which may be the most reasonable, is that histamine is known to reduce the appetite, and antihistamines, therefore, counteract this effect.
How does Periactin stimulate appetite? Cyproheptadine (Periactin) hydrochloride, a histamine and serotonin antagonist, was compared with placebo for effectiveness in producing appetite stimulation and weight gain in healthy, underweight, adults. Increase in appetite and weight was significantly greater statistically in those who received cyproheptadine.
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